A successful colostrum management program requires suppliers to consistently provide calves with a sufficient volume of clean, high-quality colostrum within the first few hours of life. are discussed. The placenta of the cow separates the maternal and fetal blood materials, preventing in utero transmission of protective immunoglobulins (Ig) [1]. Consequently, the calf is born agammaglobulinemic and so depends almost entirely around the absorption of maternal Ig from colostrum after birth. The absorption of maternal Ig across the small intestine during the first 24 hours after birth, termed passive transfer, helps to safeguard the calf against common disease organisms until its own immature immune system becomes functional. Calves are defined as AG-1517 having failure of passive transfer (FPT) if the calf serum IgG concentration is less than 10 mg/mL when sampled between 24 and 48 hours of age [2], [3]. Achieving early and adequate intake of high-quality colostrum is widely recognized as the single most important management factor in determining health and survival of the neonatal calf ( Fig.?1) [3], [4], [5], [6]. In addition AG-1517 to reduced risk for preweaning morbidity and mortality, additional long-term benefits associated with successful passive transfer include reduced mortality in the postweaning period, improved rate of gain and feed efficiency, reduced age at first calving, improved first and second lactation milk production, and reduced tendency for culling during the first lactation [7], [8], [9], [10]. Open in a separate windows Fig.?1 Calf survival by serum IgG concentration. (National animal health monitoring system. National dairy heifer evaluation project. Dairy herd management practices focusing on preweaned heifers. Ft. Collins, (CO): USDA-APHIS Veterinary Services; 1993.) Regrettably, many producers continue to incur significant loss associated with FPT. In the United States mortality rates in preweaned dairy heifers are estimated to range between 8% and 11% AG-1517 [2], [4], [11]. Poor colostrum management is one of the important factors contributing to these excessive losses. In one study 41% of 2177 calves sampled between 24 and 48 hours of age experienced FPT (serum IgG < 10 mg/mL) [2]. It was estimated that approximately 31% of preweaning mortality events occurring in the first 3 weeks of life were attributed to FPT [9]. These studies point to the need for suppliers to adopt practices to improve colostrum management. This article reviews the process of colostrogenesis and discusses important components of colostrum. The key components of developing a successful colostrum management program are discussed. Colostrogenesis and colostrum composition Bovine colostrum consists of a mixture of lacteal secretions WNT3 and constituents of blood serum, most notably Ig and other serum proteins, which accumulate in the mammary gland during the prepartum dry period [12]. This process begins several weeks before calving, under the influence of lactogenic hormones, including prolactin, and ceases abruptly at parturition. Important constituents of colostrum include Ig, maternal leukocytes, growth factors, hormones, cytokines, nonspecific antimicrobial factors, and nutrients. Concentrations of many of these components are best in the first secretions harvested after calving (first milking colostrum), then decline continuously over the next six milkings (transition milk) to reach the lower concentrations routinely measured in saleable whole milk ( Table?1) [12]. Table 1 Composition of colostrum, transition milk and whole milk of Holstein cows Hammon HM, Zanker IA, Blum JW. AG-1517 Delayed colostrum feeding affects IGF-1 and insulin plasma concentrations in neonatal calves. J Dairy Sci 2000;83:85C92; and Foley JA, Otterby DE. Availability, storage, treatment, composition, and feeding value of surplus colostrum: a review. J Dairy Sci 1978;61:1033C60. Immunoglobulins IgG, IgA, and IgM account for approximately 85% to 90%, 5%, and 7%, respectively, of the total Ig in colostrum, with IgG1 accounting for 80% to 90% of the total IgG [13]. Although levels are highly variable among cows and studies, one study reported that mean colostral concentrations of IgG, IgA, and IgM were 75 mg/mL, 4.4 mg/mL, and 4.9 mg/mL, respectively [14]. IgG, and IgG1 in particular, are transferred from your bloodstream across the mammary barrier into colostrum by a specific transport mechanism: Receptors around the mammary alveolar epithelial cells capture IgG1 from your extracellular fluid, and the molecule undergoes endocytosis, transport, and finally release into the luminal secretions [13]. The alveolar epithelial cells cease expressing this receptor, most likely in response to increasing prolactin concentrations, at the onset of lactation [15]. Smaller amounts of IgA and IgM are largely derived from local synthesis by plasmacytes in the mammary gland [13]. Although not well understood, colostral transfer of IgE also occurs and may be important in providing early protection against intestinal parasites [16]. Maternal leukocytes Normal bovine colostrum contains greater than 1 106 cells/mL of immunologically active maternal leukocytes, including macrophages, T and B lymphocytes,.